Definition
Medical indication that a problem affects the whole body rather than one localized area, like a computer virus versus a broken key. It's why some infections require full-body warfare with IV antibiotics.
Example Usage
The infection went systemic, spreading through her bloodstream and requiring aggressive treatment in the ICU.
Origin
From Greek 'systema' meaning 'organized whole,' adopted into medical use in the 18th century.
Fun Fact
Systemic medications often have more side effects than topical ones because they affect every organ system, not just the problem area.
Source: Pharmacological and pathological terminology
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